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complex(a(GO:lysosome), p(MGI:Lrrk2, var("?")))

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Components

Appears in Networks 1

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

In-Edges 0

Out-Edges 3

complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) hasComponent a(GO:lysosome) View Subject | View Object

Appears in Networks:

complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) hasComponent p(MGI:Lrrk2, var("?")) View Subject | View Object

Appears in Networks:

complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) View Subject | View Object

This is in clear contrast to other pathogenic proteins such as mutant alpha-synuclein or mutant LRRK2 that bind to lysosomes but fail to translocate through CMA (Cuervo et al., 2004; Orenstein et al., 2013) PubMed:29024336

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Annotations
MeSH
Lysosomes
Confidence
Medium
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.