act(p(PFAM:"CaMKII_AD")) positiveCorrelation a(MESH:"Reactive Oxygen Species")

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PubMed:28400318

Mechanistically, heme-derived ROS may directly modify Ca2+ handling proteins (such as the RyR2 or SERCA2a) [35, 57], and may also activate intracellular stress kinases, such as CaMKII [58], which in turn phosphorylate the same Ca2+ effectors and ultimately exacerbate Ca2+ mishandling.

Related Edges 3

• a(MESH:"Reactive Oxygen Species") positiveCorrelation act(p(PFAM:"CaMKII_AD"))
• bp(HM:"Calcium Homeostasis") negativeCorrelation act(p(PFAM:"CaMKII_AD"))
• act(p(PFAM:"CaMKII_AD")) negativeCorrelation bp(HM:"Calcium Homeostasis")

Cell Ontology (CL)

regular cardiac myocyte

Text Location

Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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