regular cardiac myocyte
As expected, α-tocopherol treatment prevented ROS accumulation and the induction of anti-oxidant genes in the heart (Figure 6A, B and see Figure 8 in [37]). PubMed:28400318
Consistently, we measured increased lipid peroxidation in both cells and tissues exposed to free heme, which can be rescued by α-tocopherol, an agent able to react with lipid radicals and interrupt the oxidation reaction. PubMed:28400318
As well as NAC, Hx co-treatment significantly improved systolic Ca2+ transients and accelerated Ca2+ transient decay kinetics, which resulted in a significant improvement of cardiomyocyte contractility (Figure 4A-E). PubMed:28400318
Consistently, we measured increased lipid peroxidation in both cells and tissues exposed to free heme, which can be rescued by α-tocopherol, an agent able to react with lipid radicals and interrupt the oxidation reaction. PubMed:28400318
In agreement with data on pro-oxidant effects of heme in neonatal mouse CMs (Figure 1D-F), oxidative stress was significantly increased in adult rat CMs exposed to free heme (see Figure 1 in [37]). PubMed:28400318
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.