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a(CHEBI:acetylcysteine)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
acetylcysteine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(MESH:"Reactive Oxygen Species") negativeCorrelation a(CHEBI:acetylcysteine) View Subject | View Object

We showed that NAC treatment scavenged ROS production and, more importantly, it counteracted ferroportin induction by heme (Fig. 8B, C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

complex(a(CHEBI:acetylcysteine), a(CHEBI:heme)) hasComponent a(CHEBI:acetylcysteine) View Subject | View Object

Appears in Networks:

path(HP:"Impaired myocardial contractility") negativeCorrelation a(CHEBI:acetylcysteine) View Subject | View Object

As well as NAC, Hx co-treatment significantly improved systolic Ca2+ transients and accelerated Ca2+ transient decay kinetics, which resulted in a significant improvement of cardiomyocyte contractility (Figure 4A-E). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

Out-Edges 3

a(CHEBI:acetylcysteine) negativeCorrelation path(HP:"Impaired myocardial contractility") View Subject | View Object

As well as NAC, Hx co-treatment significantly improved systolic Ca2+ transients and accelerated Ca2+ transient decay kinetics, which resulted in a significant improvement of cardiomyocyte contractility (Figure 4A-E). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

a(CHEBI:acetylcysteine) negativeCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

We showed that NAC treatment scavenged ROS production and, more importantly, it counteracted ferroportin induction by heme (Fig. 8B, C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:acetylcysteine) decreases p(MGI:Slc40a1) View Subject | View Object

We showed that NAC treatment scavenged ROS production and, more importantly, it counteracted ferroportin induction by heme (Fig. 8B, C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.