act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))

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PubMed:28784767

When combined with ERK2 catalyzed phosphorylation, the turn-like disrupting G207V mutation in TauF8 hence leads to fast aggregation that already occurs during the phosphorylation reaction.

Related Edges 5

• act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
• p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn")
• p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn")
• p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("pGly207Val")) increases bp(HBP:"Tau aggregates")

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