path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")

PubMed:24511233

1 Several lines of evidence suggest that impaired cholinergic signaling plays a key role in mediating both the cognitive and the behavioral impairments observed in AD patients.12 The basal forebrain cholinergic system is disproportionately affected in AD patients, with a robust loss of cholinergic neurons, including those innervating the hippocampus and cortex.

Related Edges 5

• bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition)
• bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior)
• bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic")
• bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic")
• path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic")

MeSH

Cerebral Cortex

MeSH

Hippocampus

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