epithelial cell
Renal tissues from old blood-transfused animals exhibited 4-HNE-positive staining. PubMed:26794659
In old blood-transfused animals, strong Hb and iron deposition was observed in the tubule lumen and epithelial cells, respectively. PubMed:26794659
This ATP depletion was prevented by the addition of the heme scavenger, hemopexin (Figure 5b). PubMed:26794659
Reduced glutathione (GSH) was also depleted after 4 h of heme exposure, indicating that heme induces oxidative stress in exposed cells (Figure 5c). PubMed:26794659
The above-discussed findings provide strong in vivo evidence that high concentrations of ferric Hb(Fe3+) and free heme can accumulate in the renal cortex during hemolysis. PubMed:26794659
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.