CA3 Region, Hippocampal
In CA1 and CA3 pyramidal neurons of the developed hippocampus, alpha7 nAChRs are expressed primarily on axon terminals whereby their activation modulates the efficacy of glutamate synaptic transmission. PubMed:19126755
In the rat CA3 region, spontaneous activation of GABA A receptors produces giant depolarizing potentials, whose frequency is controlled by α7∗ and non-α7 nAChRs. PubMed:17009926
In the rat CA3 region, spontaneous activation of GABA A receptors produces giant depolarizing potentials, whose frequency is controlled by α7∗ and non-α7 nAChRs. PubMed:17009926
Corroborating this hypothesis, it has been demonstrated that dopamine efflux is increased in the nucleus accumbens of M4 knockout mice PubMed:26813123
In addition to cognitive alterations, psychiatric symptoms are frequently observed in AD patients, including apathy and depression PubMed:26813123
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