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p(HGNC:NLRP1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
NLRP1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 6

a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) View Subject | View Object

NLRP1 recognizes muramyl dipeptide, which is a bacterial peptidoglycan PubMed:23702978

Appears in Networks:
Annotations
Confidence
Low

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:NLRP1), p(HGNC:NOD2)) hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

Out-Edges 2

p(HGNC:NLRP1) increases p(HGNC:IL18) View Subject | View Object

For example, down-regulation of NLRP1 in macrophages trigger by Cordyceps sinensis mycelium reduces both IL-18 and IL-1β levels (Huang et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:NLRP1) increases p(HGNC:IL1B) View Subject | View Object

For example, down-regulation of NLRP1 in macrophages trigger by Cordyceps sinensis mycelium reduces both IL-18 and IL-1β levels (Huang et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.