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complex(a(MESH:Proteins), p(HGNC:HSPA8))

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Components

Appears in Networks 1

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 2

p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) View Subject | View Object

CMA is a process in which proteins harboring a pentapeptide motif related to the sequence KFERQ are specifically recognized by a cytosolic chaperone, the heat shock cognate protein of 70 kDa (hsc70). PubMed:18930136

Appears in Networks:

p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) View Subject | View Object

The substrate-chaperone complex is then targeted to the lysosome by binding to lysosome-associated membrane protein 2A (LAMP-2A) which carries out receptor-mediated translocation of the substrate into the lysosome for degradation [11,13] PubMed:18930136

Appears in Networks:

Out-Edges 2

complex(a(MESH:Proteins), p(HGNC:HSPA8)) hasComponent a(MESH:Proteins) View Subject | View Object

Appears in Networks:

complex(a(MESH:Proteins), p(HGNC:HSPA8)) hasComponent p(HGNC:HSPA8) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.