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bp(MESH:D009435)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
D009435
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh.belns

Appears in Networks 1

Interplay of neurotransmitters in Alzheimer's disease v1.0.0

In-Edges 2

a(CHEBI:memantine) causesNoChange bp(MESH:D009435) View Subject | View Object

According to the proposed hypothesis, memantine has the ability to block the passage of Ca2+ through the calcium channel even when, as in Alzheimer's disease, resting synaptic glutamate levels are abnormally high, but it is still readily displaced at peak synaptic glutamate concentrations.13 In other words, the clinical efficacy of memantine appears to stem from its ability to prevent neuronal overactivity without also hindering normal neurotransmission. PubMed:16273023

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

path(MESH:D000544) decreases bp(MESH:D009435) View Subject | View Object

Although the loss of neurons leads to deficits in neurotransmission, even neurons that are not dead may exhibit impaired neurotransmission in Alzheimer's disease PubMed:16273023

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.