a(MESH:Alarmins)
In response to danger signals, inflammasomes assemble by self-oligomerizing the NLRs through interactions with the NACHT domain (van de Veerdonk et al., 2011) PubMed:24561250
The activators of the inflammasomes can be divided into two categories; pathogen associated molecular patterns (PAMPs) activate a host-defense reaction, and damage associated molecular patterns (DAMPs) activate a self-defense mechanism in response to danger signals (Salminen et al., 2008) PubMed:24561250
In recent years, it has also been shown that toll-like receptors and other pattern recognition receptors are activated not only by extrinsic factors but also by intrinsic stimuli (so called damage-associated molecular patterns, DAMPs) that are released when the host cell is damaged [27, 29]. PubMed:29956069
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