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Out-Edges 3

a(MESH:Alarmins) increases complex(GO:"inflammasome complex") View Subject | View Object

In response to danger signals, inflammasomes assemble by self-oligomerizing the NLRs through interactions with the NACHT domain (van de Veerdonk et al., 2011) PubMed:24561250

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High

a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

The activators of the inflammasomes can be divided into two categories; pathogen associated molecular patterns (PAMPs) activate a host-defense reaction, and damage associated molecular patterns (DAMPs) activate a self-defense mechanism in response to danger signals (Salminen et al., 2008) PubMed:24561250

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Confidence
High

a(MESH:Alarmins) increases act(p(HGNC:TLR4)) View Subject | View Object

In recent years, it has also been shown that toll-like receptors and other pattern recognition receptors are activated not only by extrinsic factors but also by intrinsic stimuli (so called damage-associated molecular patterns, DAMPs) that are released when the host cell is damaged [27, 29]. PubMed:29956069

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MeSH
Arteries
MeSH
Sepsis
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Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.