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a(HP:"cholinergic neuron")

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Entity

Name
cholinergic neuron
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

In-Edges 3

bp(GO:cognition) association a(HP:"cholinergic neuron") View Subject | View Object

Several studies demonstrated the pivotal role of these cholinergic nuclei in cognitive functions PubMed:25514383

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron") View Subject | View Object

In addition, anatomical studies in AD patients showed a massive loss of brain white matter and a specific reduction of cholinergic neurons of the basal forebrain (Auld et al., 2002; Bowen et al., 1976; Coyle et al., 1983; Kim et al., 2013; Whitehouse et al., 1981, 1982) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Basal Forebrain

path(MESH:Attention) association a(HP:"cholinergic neuron") View Subject | View Object

The cholinergic system is also involved in attention processes (Muir et al., 1993; Sarter and Bruno, 1997; Wenk, 1997) PubMed:25514383

Appears in Networks:

Out-Edges 4

a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In addition, anatomical studies in AD patients showed a massive loss of brain white matter and a specific reduction of cholinergic neurons of the basal forebrain (Auld et al., 2002; Bowen et al., 1976; Coyle et al., 1983; Kim et al., 2013; Whitehouse et al., 1981, 1982) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Basal Forebrain

a(HP:"cholinergic neuron") association bp(GO:cognition) View Subject | View Object

Several studies demonstrated the pivotal role of these cholinergic nuclei in cognitive functions PubMed:25514383

Appears in Networks:

a(HP:"cholinergic neuron") increases bp(GO:cognition) View Subject | View Object

The role of the cholinergic system in cognition and the modification observed in neurodegenerative diseases, and in particular in the case of AD, led to the formulation of the “cholinergic hypothesis” of geriatric disorders (Bartus et al., 1982; Contestabile, 2011), according to which the reduction in cholinergic innervation is responsible for the cognitive decline observed in AD patients PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HP:"cholinergic neuron") association path(MESH:Attention) View Subject | View Object

The cholinergic system is also involved in attention processes (Muir et al., 1993; Sarter and Bruno, 1997; Wenk, 1997) PubMed:25514383

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.