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a(PUBCHEM:377503130)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
377503130
Namespace
PUBCHEM
Namespace Version
None
Pattern
^\d+$

Appears in Networks 1

The Biology of Proteostasis in Aging and Disease v1.0.0

In-Edges 0

Out-Edges 2

a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) View Subject | View Object

High-throughput screens in yeast and HeLa cells identified HSF1A and F1, respectively, as two small molecules that activate HSF1 independently of HSP90 inhibition (136, 137). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) View Subject | View Object

HSF1A suppresses toxicity in cell and tissue culture models of HD and SCA-3/MJD and appears to activate HSF1 by impairing the activity of TRiC, a recently discovered negative regulator of HSF1. PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.