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bp(HM:"Renal Blood Flow, limited")

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Entity

Name
Renal Blood Flow, limited
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 5

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

By contrast, no or limited increases in renal blood flow are observed during acute hemodilution (15, 42), leading to earlier and more severe renal tissue hypoxia (5, 38), and an increase in the magnitude of hypoxia signaling responses, including stabilization of the transcription factor hypoxia- inducible factor- (HIF-) (42, 43). PubMed:29351418

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MeSH
Kidney
Text Location
Introduction

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

The absent or relatively small increase in renal blood flow likely contributed to the occurrence of renal tissue hypoxia in both models. PubMed:29351418

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Annotations
MeSH
Kidney
Text Location
Discussion

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

The renal blood flow response to anemia is proportionally much smaller than the increase observed in cerebral blood flow (50–100%). This relative difference in organ blood flow likely explains why the kidney becomes profoundly hypoxic, whereas brain oxygenation is largely preserved during anemia (12, 32, 42). PubMed:29351418

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Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

Our data provided clear evidence of renal tissue hypoxia, which was in part due to a lack of increase in renal blood flow. PubMed:29351418

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Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

bp(HM:"Renal Blood Flow, limited") increases p(HGNC:HIF1A) View Subject | View Object

By contrast, no or limited increases in renal blood flow are observed during acute hemodilution (15, 42), leading to earlier and more severe renal tissue hypoxia (5, 38), and an increase in the magnitude of hypoxia signaling responses, including stabilization of the transcription factor hypoxia- inducible factor- (HIF-) (42, 43). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Introduction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.