a(HBP:HBP00030)
The ApoE4 allele is most important genetic risk factor for AD, while the ApoE2 allele is thought to be protective. PubMed:21718217
The ApoE4 allele is most important genetic risk factor for AD, while the ApoE2 allele is thought to be protective. PubMed:21718217
Mice expressing the ApoE4 isoform exhibited higher levels of Ab deposition in comparison to ApoE3 or ApoE2 expressing animals [36]. PubMed:21718217
Third, apolipoprotein E allele 4 (APOE4), a major risk allele for sporadic AD, is associated with increased generation and accumula- tion of Aβ42 (REFS59,60) . PubMed:30116051
Third, apolipoprotein E allele 4 (APOE4), a major risk allele for sporadic AD, is associated with increased generation and accumula- tion of Aβ42 (REFS59,60) . PubMed:30116051
In addition to decreased degradation, one consequence is leakage of asparaginyl endopeptidase into the cytosol, where it generates toxic fragments of tau 61 . PubMed:30116051
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