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p(HGNC:TLR2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
TLR2
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 2

Alpha-synuclein oligomers: a new hope v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

a(HBP:HBP00093) increases act(p(HGNC:TLR2)) View Subject | View Object

Kim et al. demonstrated that a-syn oligomers lead to microglial inflammatory responses via TLR2 activation [74]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Microglia

a(CHEBI:heme) increases p(HGNC:TLR2) View Subject | View Object

Heme amplifies cytokines induced by cell surface receptors (TLR2, TLR4, TLR5), endosome receptors (TLR3, TLR9), and cytosolic receptors (NOD1 and NOD2). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

Out-Edges 1

p(HGNC:TLR2) increases a(MESH:Cytokines) View Subject | View Object

Haem increases lethality and cytokine secretion induced by LPS in vivo and enhances cytokine secretion by macrophages stimulated with various innate immune receptor agonists (e.g., TLR2, TLR9, TLR3, and nucleotide-binding oligomerization domain (NOD) agonists) (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.