Evidences a(MESH:Neurons) to p(HGNC:MAPT)

In addition, stimulating neuronal activity in either cultured neurons or in vivo also enhances tau release

this observation suggests that the activity-dependent release of tau participates in a positive feedback loop on neuronal activity.

CSF tau in APP transgenic mice is increased in an age- dependent manner without a global neuronal loss

the application of extracellular tau increases the electrical activity of iPSC-derived or primary cortical neurons

Moreover, extracellular tau may elicit cellular toxicity under certain conditions.

These studies indicate that the endogenous tau plays a part in regulating neuronal activity

Intraneuronal iron accumulation, neuronal loss in the substantia nigra and a severe decline in locomotor functions were observed in 12‑month-old tau-knockoutmice

Although tau function can be partly compensated by other, redundant microtubule-associated proteins (for example, MAP1A), the behavioural impairments observed in aged (~12‑month-old) tau-knockout mice indicate that tau is necessary for normal neuronal and brain function.

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.