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p(HBP:HBP00053, var("p.Lys280del"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00053
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

In-Edges 3

p(HBP:HBP00053) hasVariant p(HBP:HBP00053, var("p.Lys280del")) View Subject | View Object

Appears in Networks:

p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) View Subject | View Object

This conformational change, but not the aggregation itself, interferes also with tau degradation by e-MI, as we found a significant decrease in the uptake of both mutants by LE (Fig. 6d,e) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
High
MeSH
Brain

p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) View Subject | View Object

Thus, insertion of two prolines in the DK280 background (hTau40 DK280/2P), which prevents tau aggregation (Barghorn & Mandelkow, 2002), only partially rescued CMA uptake of the DK280 mutant (Fig. 6a,b) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
High
MeSH
Brain

Out-Edges 3

p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006) View Subject | View Object

Interestingly, a deletion of lysine 280 (hTau40 DK280), known to lead to tau aggregation (Khlistunova et al., 2006), turned this protein into a very poor CMA substrate (Fig. 6a,b) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
Medium
MeSH
Brain

p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) View Subject | View Object

Interestingly, a deletion of lysine 280 (hTau40 DK280), known to lead to tau aggregation (Khlistunova et al., 2006), turned this protein into a very poor CMA substrate (Fig. 6a,b) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
Medium
MeSH
Brain

p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) View Subject | View Object

This conformational change, but not the aggregation itself, interferes also with tau degradation by e-MI, as we found a significant decrease in the uptake of both mutants by LE (Fig. 6d,e) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
High
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.