p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")
In fact, the B subunit is now known to contain multiple WD40 repeats [28], whereas B′′/PR72 is thought to contain two calcium-binding EF hands PubMed:19277525
More specifically, decreased expression levels of PP2A regulatory Bγ (or PPP2R2C) and B’ε (or PPP2R5E) subunit mRNAs in the hippocampus (Vogelsberg-Ragaglia et al.,2001), and cortical Bα subunit (Sontag et al.,2004b) have been reported in AD. PubMed:24653673
To gain full activity towards specific substrates, the PP2A core enzyme interacts with a variable regulatory subunit to form a heterotrimeric holoenzyme. The variable regulatory subunits consist of four families: B (also known as B55 or PR55), B′ (B56 or PR61), B′′ (PR48/PR72/PR130), and B′′′ (PR93/PR110), with at least 16 members in these families PubMed:19277525
Except the B′′′ subunits, direct interactions between the PP2A core enzyme and the regulatory subunits have been demonstrated PubMed:19277525
Structure of the heterotrimeric PP2A holoenzyme involving a regulatory B subunit (Figure 2D) reveals how B subunit specifically recognizes the PP2A core enzyme and how it may facilitate substrate dephosphorylation PubMed:19277525
In fact, the B subunit is now known to contain multiple WD40 repeats [28], whereas B′′/PR72 is thought to contain two calcium-binding EF hands PubMed:19277525
Structure of the heterotrimeric PP2A holoenzyme involving a regulatory B subunit (Figure 2D) reveals how B subunit specifically recognizes the PP2A core enzyme and how it may facilitate substrate dephosphorylation PubMed:19277525
Unlike the PP2A holoenzyme involving the B′ subunit, B makes few interactions with the catalytic subunit PubMed:19277525
This analysis further suggests that the B subunit may form a relatively stable complex with the isolated scaffold subunit and does not seem to support the notion that the catalytic subunit is required for interaction between the scaffold and the B subunits PubMed:19277525
Previous investigations indicate that specific dephosphorylation of Tau appeared to be mediated by the B family of regulatory subunits PubMed:19277525
For instance, the Bα subunit specifically and markedly facilitates dephosphory- lation of tau by PP2A (Sontag et al.,1996; Xu et al.,2008). PubMed:24653673
For instance, the Bα subunit specifically and markedly facilitates dephosphory- lation of tau by PP2A (Sontag et al.,1996; Xu et al.,2008). PubMed:24653673
For instance, some B’ subunits target PP2A to the nucleus (McCright et al., 1996) or the centrosome (Flegg et al.,2010); Bα subunits can direct some PP2A pools to microtubules, which could serve as a cytoskeletal reservoir of inac- tive enzymes (Sontag et al.,1995; Hiraga and Tamura,2000). PubMed:24653673
More specifically, decreased expression levels of PP2A regulatory Bγ (or PPP2R2C) and B’ε (or PPP2R5E) subunit mRNAs in the hippocampus (Vogelsberg-Ragaglia et al.,2001), and cortical Bα subunit (Sontag et al.,2004b) have been reported in AD. PubMed:24653673
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.