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p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPP2CA
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 5

bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) View Subject | View Object

PP2A enzymes can also become transiently inactivated following tyrosine phosphorylation of the catalytic subunit at the putative Tyr-307 site,via activation of src kinase, epidermal growth factor receptor or insulin signaling (Chen et al.,1992). PubMed:24653673

Appears in Networks:

p(HGNC:PPP2CA) hasVariant p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) View Subject | View Object

Appears in Networks:

p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) View Subject | View Object

PP2A enzymes can also become transiently inactivated following tyrosine phosphorylation of the catalytic subunit at the putative Tyr-307 site,via activation of src kinase, epidermal growth factor receptor or insulin signaling (Chen et al.,1992). PubMed:24653673

Appears in Networks:

p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) View Subject | View Object

PP2A enzymes can also become transiently inactivated following tyrosine phosphorylation of the catalytic subunit at the putative Tyr-307 site,via activation of src kinase, epidermal growth factor receptor or insulin signaling (Chen et al.,1992). PubMed:24653673

Appears in Networks:

p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) View Subject | View Object

Besides Ser/Thr kinases, the protein tyrosine kinase src promotes the phosphorylation of PP2A on Tyr-307, resulting in PP2A inactivation and subsequent tau phosphorylation (Xiong et al.,2013; Arif et al.,2014). PubMed:24653673

Appears in Networks:

Out-Edges 2

p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

PP2A enzymes can also become transiently inactivated following tyrosine phosphorylation of the catalytic subunit at the putative Tyr-307 site,via activation of src kinase, epidermal growth factor receptor or insulin signaling (Chen et al.,1992). PubMed:24653673

Appears in Networks:

p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Besides Ser/Thr kinases, the protein tyrosine kinase src promotes the phosphorylation of PP2A on Tyr-307, resulting in PP2A inactivation and subsequent tau phosphorylation (Xiong et al.,2013; Arif et al.,2014). PubMed:24653673

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.