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p(HGNC:SERPINF2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SERPINF2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

In-Edges 2

path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2) View Subject | View Object

However, the levels and activity of plasmin are reduced in AD brains (Ledesma et al. 2000) PubMed:29626319

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2)) View Subject | View Object

However, the levels and activity of plasmin are reduced in AD brains (Ledesma et al. 2000) PubMed:29626319

Appears in Networks:

Out-Edges 4

p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

However, the levels and activity of plasmin are reduced in AD brains (Ledesma et al. 2000) PubMed:29626319

Appears in Networks:

p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Extracellular Aβ degrading enzymes include neprilysin (NEP), insulin-degrading enzyme (IDE), matrix metalloproteinases (MMPs), angiotensin converting enzyme (ACE), endothelin-converting enzyme (ECE), and plasmin (Baranello et al. 2015) PubMed:29626319

Appears in Networks:

p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Brain plasmin degrades Aβ PubMed:29626319

Appears in Networks:

act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

However, the levels and activity of plasmin are reduced in AD brains (Ledesma et al. 2000) PubMed:29626319

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.