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  3. a(HBP:HBP00069)

a(HBP:HBP00069)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00069
Namespace
HBP
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/bd0996a28201cad363557315043c6392e31abf58/export/hbp.belns

Appears in Networks 2

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 4

complex(a(HBP:HBP00069), p(HGNC:APP)) hasComponent a(HBP:HBP00069) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) hasProduct a(HBP:HBP00069) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) hasProduct a(HBP:HBP00069) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) hasProduct a(HBP:HBP00069) View Subject | View Object

Appears in Networks:

Out-Edges 3

a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713")) View Subject | View Object

C31 also appears to induce a caspase-independent toxicity by selectively increasing Abeta42 (Dumanchin-Njock et al. 2001) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

a(HBP:HBP00069) increases bp(HBP:HBP00061) View Subject | View Object

Caspase-cleavages of APP are thought to be harmful because both C31 and the Jcasp fragment generated were found to be cytotoxic (Lu et al. 2003a) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

a(HBP:HBP00069) increases act(p(HGNC:CASP3)) View Subject | View Object

However, C31, a short form of AICD generated by caspase cleavage, has been reported to directly activate caspase 3 in the tumor cell death process (Lu et al. 2000; Bertrand et al. 2001; Nishimura et al. 2002; Madeira et al. 2005) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.