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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

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a(CHEBI:heme) positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

Furthermore, free heme also induced extracellular release of HMGB1 from RMVECs compared to vehicle control (Fig 5B). PubMed:29522519

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a(CHEBI:heme) positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

In summary, these results indicate that heme from resuscitation with stored RBCs increases extracellular release of HMGB1, which inhibits macrophage phagocytosis of P. aeruginosa, leading to increased mortality. PubMed:29522519

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a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

Fig 5A shows that extracellular serum levels of HMGB1 were approximately 5-fold higher in mice (n = 3) resuscitated with stored RBCs compared to mice resuscitated fresh RBCs. PubMed:29522519

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p(MGI:Hmgb1) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Fig 5A shows that extracellular serum levels of HMGB1 were approximately 5-fold higher in mice (n = 3) resuscitated with stored RBCs compared to mice resuscitated fresh RBCs. PubMed:29522519

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p(MGI:Hmgb1) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Furthermore, free heme also induced extracellular release of HMGB1 from RMVECs compared to vehicle control (Fig 5B). PubMed:29522519

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p(MGI:Hmgb1) positiveCorrelation a(CHEBI:heme) View Subject | View Object

In summary, these results indicate that heme from resuscitation with stored RBCs increases extracellular release of HMGB1, which inhibits macrophage phagocytosis of P. aeruginosa, leading to increased mortality. PubMed:29522519

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p(MGI:Hmgb1) decreases bp(GO:phagocytosis) View Subject | View Object

In summary, these results indicate that heme from resuscitation with stored RBCs increases extracellular release of HMGB1, which inhibits macrophage phagocytosis of P. aeruginosa, leading to increased mortality. PubMed:29522519

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macrophage
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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.