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p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0

In-Edges 1

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) View Subject | View Object

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Out-Edges 1

p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT)) View Subject | View Object

Thus, for our initial studies we engineered and purified full-length (FL) tau monomer that lacks any internal cysteines due to alanine substitu- tions (C299A and C322A), termed tau (2A). FL tau (2A) cannot self-associate based on disulfide link- ages, which helped prevent the formation of cryptic dimers that could have confounded our studies. PubMed:29988016

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.