Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
non-enzymatic protein modification
Namespace
HBP
Namespace Version
20190309
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/0c9853baf883545b922ff1b138a9f297a70b7951/export/hbp-names.belns

Appears in Networks 1

In-Edges 2

a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification") View Subject | View Object

Free radicals-derived protein modification can result in either gain- or loss-of-function due to the protein misfolding or unfolding. PubMed:24563850

bp(GO:aging) positiveCorrelation bp(HBP:"non-enzymatic protein modification") View Subject | View Object

Proteome is modified post-translationally by either numerous highly regulated enzymatic protein modifications (EPMs) (e.g. phosphorylation, acetylation, ubiquitination, methylation, etc.) or by non-enzymatic protein modifications (NEPMs), which are mostly stochastic and increase with ageing or in age-related diseases (Fig. 1). PubMed:24563850

Out-Edges 2

bp(HBP:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) View Subject | View Object

Proteome is modified post-translationally by either numerous highly regulated enzymatic protein modifications (EPMs) (e.g. phosphorylation, acetylation, ubiquitination, methylation, etc.) or by non-enzymatic protein modifications (NEPMs), which are mostly stochastic and increase with ageing or in age-related diseases (Fig. 1). PubMed:24563850

bp(HBP:"non-enzymatic protein modification") increases bp(HBP:misfolding) View Subject | View Object

EPMs alter the targeted proteins, which however remain fully functional, while NEPMs may induce protein unfolding or misfolding resulting in increased proteome instability. PubMed:24563850

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.