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p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208))

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
Triosephosphate isomerase
Namespace
interpro
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/interpro-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

p(INTERPRO:"Triosephosphate isomerase") hasVariant p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) View Subject | View Object

Ab induced nitro-oxidative stress on human neuroblastoma cells, resulting in nitrotyrosination of TPI. Moreover, higher levels of nitro-TPI were also detected in extracts from hippocampus (Fig. 1F) and frontal cortex (Fig. 1G) obtained from Alzheimer’s disease brains, compared with healthy subjects. PubMed:19251756

Appears in Networks:
Annotations
Uberon
frontal cortex
Uberon
hippocampal formation
Disease Ontology (DO)
Alzheimer's disease

Out-Edges 3

p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Ab induced nitro-oxidative stress on human neuroblastoma cells, resulting in nitrotyrosination of TPI. Moreover, higher levels of nitro-TPI were also detected in extracts from hippocampus (Fig. 1F) and frontal cortex (Fig. 1G) obtained from Alzheimer’s disease brains, compared with healthy subjects. PubMed:19251756

Appears in Networks:
Annotations
Uberon
frontal cortex
Uberon
hippocampal formation
Disease Ontology (DO)
Alzheimer's disease

p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) View Subject | View Object

Nitration of Tyr164 and Tyr208 would destabilize the closed state of loop 6 because the interaction between Tyr208 and Ala176 through an H-bond would be compromised (Fig. 2A and B; Supplementary Fig. S2). Indeed, purified TPI after nitrotyrosination with a peroxynitrite donor (SIN-1) displayed a significant decrease in isomerase activity in both directions of the catalysis, i.e. using DHAP (Fig. 2C) or GAP (Fig. 2D) as substrate. PubMed:19251756

Appears in Networks:

p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) View Subject | View Object

Appears in Networks:

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.