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p(HGNC:CHRNA7, var("p.Trp55Ala"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHRNA7
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

In-Edges 1

p(HGNC:CHRNA7) hasVariant p(HGNC:CHRNA7, var("p.Trp55Ala")) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) View Subject | View Object

There is evidence that ApoE directly interacts with nAChRs. An APOE-derived peptide blocks nAChRs on rat hippocampal slices with a submicromolar affinity, and this action is dependent on an arginine-rich segment of the APOE peptide (Klein and Yakel, 2004). Block of heterologously expressed alpha7 nAChRs is greater than that for alpha4beta2 or alpha2beta2 nAChRs (Gay et al., 2006). This block of alpha7 receptors is abolished when alpha7 Trp55 is mutated to alanine, providing strong evidence that it results from a direct interaction between the peptide and the receptors (Gay et al., 2007), and the effects of other substitutions of Trp55 suggests that this interaction is hydrophobic PubMed:19293145

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.