PubMed 30008470

Importantly, Adnp+/− females showed higher alcohol consumption and preference, compared to female Adnp+/+ controls, whereas no difference was observed in males.

BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking")
Hash
33d2e5c25c
Gender
Female
Species
10090
Networks
BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking")
Hash
8ae075f929
Gender
Male
Species
10090
Networks

PubMed 30008470

As shown in Fig. 3e, f, we found no difference between genotypes in saccharin or quinine intake, suggesting that the effect of Adnp deficiency is specific to alcohol, and does not apply to sweet reinforcers or bitter-taste solutions

BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking")
Hash
406b722dbd
Gender
Female
Species
10090
Networks

PubMed 30008470

As Fig. 4b depicts, over the first 2 weeks of drinking (no treatment or intranasal vehicle treatment) Adnp+/− females showed higher alcohol consumption as compared to their Adnp+/+ littermates, replicating our results above.

BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking")
Hash
63986ef4da
Gender
Female
Species
10090
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.