PubMed 30664622

In females, hippocampal VGLUT1 was not affected by the Adnp genotype or NAP treatment (Supplemental Fig. S4A)

BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7)
Hash
77ca0d0edd
Gender
Female
MeSHAnatomy
Hippocampus
Species
10090
Networks

PubMed 30664622

In the cerebral cortex, female Adnp+/− mice exhibited significantly reduced VGLUT1 expression, with no effect for NAP (Supplemental Fig. S4B).

BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7)
Hash
14dd21f00f
Gender
Female
MeSHAnatomy
Cerebral Cortex
Species
10090
Networks

PubMed 30664622

At the protein level, a significant reduction in VGLUT1 was observed in both the hippocampus (Fig. 4c–e, immunohistochemistry, 4FG, densitometry) and cerebral cortex (Fig. 4h, i, densitometry).

BEL
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7)
Hash
42293761a8
MeSHAnatomy
Hippocampus, Cerebral Cortex
Species
10090
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.