p(MGI:Chrm3)

Entity

Name

Chrm3

Namespace

mgi

Namespace Version

20181021

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

M3 mAChR is expressed at a relatively high level in the hypothalamus, but is also found in many other regions including the hippocampus[47]. Mice lacking M3 mAChR appear hypophagic and lean, suggesting a general function of M2 mAChR in regulating food intake[50]. PubMed:24590577

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577