p(HGNC:GPR37)
It then aggregates, and the insoluble protein elicits cell death via the Unfolded Protein Response (UPR). PubMed:14556719
A second important substrate of Parkin is the Parkin-associated endothelial-like (Pael) receptor, a putative G protein-coupled transmembrane polypeptide (Imai et al., 2001). When overexpressed in cells, the receptor becomes misfolded PubMed:14556719
Parkin ubiquitinates and promotes the degradation of the insoluble Pael receptor, acting in this reaction along Ubc6 and Ubc7, two E2s located in the ER PubMed:14556719
Importantly, the insoluble Pael receptor accumulates in the brains of patients with AR-JP PubMed:14556719
A second important substrate of Parkin is the Parkin-associated endothelial-like (Pael) receptor, a putative G protein-coupled transmembrane polypeptide (Imai et al., 2001). When overexpressed in cells, the receptor becomes misfolded PubMed:14556719
A second important substrate of Parkin is the Parkin-associated endothelial-like (Pael) receptor, a putative G protein-coupled transmembrane polypeptide (Imai et al., 2001). When overexpressed in cells, the receptor becomes misfolded PubMed:14556719
It then aggregates, and the insoluble protein elicits cell death via the Unfolded Protein Response (UPR). PubMed:14556719
Importantly, the insoluble Pael receptor accumulates in the brains of patients with AR-JP PubMed:14556719
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.