1. Catalog
  2. Nodes
  3. complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species"))

complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

deg(p(HGNC:HBB)) positiveCorrelation complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species")) View Subject | View Object

Spontaneous decomposition of Hb via auto-oxidation leads to the formation of ROS, free heme groups and free iron, which are highly reactive and have the ability to damage lipids, proteins, and DNA (Olsson et al., 2012). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

Out-Edges 4

complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species")) hasComponent a(CHEBI:"iron(2+)") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species")) hasComponent a(CHEBI:heme) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species")) hasComponent a(MESH:"Reactive Oxygen Species") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species")) positiveCorrelation deg(p(HGNC:HBB)) View Subject | View Object

Spontaneous decomposition of Hb via auto-oxidation leads to the formation of ROS, free heme groups and free iron, which are highly reactive and have the ability to damage lipids, proteins, and DNA (Olsson et al., 2012). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.