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p(FPLX:GABR)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
GABR
Namespace
FPLX
Namespace Version
20180917
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

Appears in Networks 3

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease v1.0.0

In-Edges 3

a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") hasMember p(FPLX:GABR) View Subject | View Object

Appears in Networks:

p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) View Subject | View Object

NACHO does not affect function of ion channels gated by numerous other ligands including glutamate, GABA, serotonin, and capsaicin, suggesting that NACHO represents the only essential client-specific chaperone yet identified for any mammalian neurotransmitter receptor (Gu et al., 2016) PubMed:28445721

Appears in Networks:

act(p(HGNC:HSD17B10)) association p(FPLX:GABR) View Subject | View Object

Moreover, function of ABAD has also been associated with GABA A receptors, as it catalyzes the oxidation of the neurosteroids allopregnanolone and allotetrahydrodeoxycorticosterone, both of which are positive modulators of GABA A receptors in the brain. PubMed:30444369

Appears in Networks:

Out-Edges 1

p(FPLX:GABR) association act(p(HGNC:HSD17B10)) View Subject | View Object

Moreover, function of ABAD has also been associated with GABA A receptors, as it catalyzes the oxidation of the neurosteroids allopregnanolone and allotetrahydrodeoxycorticosterone, both of which are positive modulators of GABA A receptors in the brain. PubMed:30444369

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.