PubMed 28745240

Another known target of NF-κB, TNFα [266, 267] is also up-regulated in the cortex [268], cerebrospinal fluid, and the serum of Alzheimer’s disease patients

PubMed 28745240

Furthermore, Amyloid-β actuates NF-κB – dependent pro-inflammatory pathways in microglia culminating in TNFα expression and subsequently TNFα effectuated neurotoxicity

PubMed 28745240

Amyloid-β also induces microglial activation that results in NF-κB – induced expression of pro-inflammatory cytokines such as TNFα, IL1β, IL6, and IL8 from the microglia resulting in neuronal death

PubMed 25652642

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients

PubMed 21958873

We observed that anatabine dose dependently inhibited NFκB activation by TNFα in HEK293 NFκB luciferase reporter cells (Fig. 5) whereas nicotine was ineffective

BEL
p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex"))
Hash
653fa3ff36
CellLine
CHO cell
Networks

PubMed 25331948

For instance, the small GTPase Rho and its downstream effector Rho-associated coiled-coil containing protein kinase (ROCK) have been shown to contribute to TNFα induction of NFkB activation (45).

PubMed 28745240

The trophic factors that evoke proliferation of NPC by inducing activation of NF-κB include epidermal growth factor (EGF) [155-161], basic fibroblast growth factor (bFGF) [155-161], vascular endothelial growth factor (VEGF) [162], tumor necrosis factor α (TNFα) [163], and erythropoietin (EPO)

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.