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M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(MESH:"WAY 132983") increases path(MESH:Hypothermia) View Subject | View Object

Similarly, the M1 agonist WAY-132983 at a low dose improves cognitive status in animal models but at a high dose causes side-effects such as salivation and hypothermia[102, 112]. PubMed:24590577

path(MESH:"Systemic Inflammatory Response Syndrome") positiveCorrelation path(MESH:Hypothermia) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

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path(MESH:Sepsis) positiveCorrelation path(MESH:Hypothermia) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

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path(MESH:Hypothermia) positiveCorrelation path(MESH:"Systemic Inflammatory Response Syndrome") View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

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path(MESH:Hypothermia) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.