Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 5

In-Edges 5

act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") View Subject | View Object

Further highlighting the importance of the cholinergic system in the CNS, cholinergic neuronal loss, especially in the basal forebrain, occurs not only in AD, but also in Parkinson’s disease [190, 191], Down syndrome [192], amyotrophic lateral sclerosis [193, 194], progressive supranuclear palsy [195, 196], and olivopontocerebellar atrophy [197] PubMed:26813123

p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome") View Subject | View Object

Decreased of PP2A, but not of other phosphatases, has also been observed in Down syndrome correlating with increased tau pathology. PubMed:22299660

bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") View Subject | View Object

Similar endosomal anomalies develop gradually in Down syndrome brain, beginning decades before the appearance of classical AD pathology (Cataldo et al. 2000). PubMed:22908190

Out-Edges 6

path(MESH:"Down Syndrome") increases a(HBP:HBP00018) View Subject | View Object

As DS also results in Abeta accumulation, the genes location suggests a link between BACE2 and APP processing PubMed:21214928

Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") View Subject | View Object

Further highlighting the importance of the cholinergic system in the CNS, cholinergic neuronal loss, especially in the basal forebrain, occurs not only in AD, but also in Parkinson’s disease [190, 191], Down syndrome [192], amyotrophic lateral sclerosis [193, 194], progressive supranuclear palsy [195, 196], and olivopontocerebellar atrophy [197] PubMed:26813123

path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2) View Subject | View Object

Decreased of PP2A, but not of other phosphatases, has also been observed in Down syndrome correlating with increased tau pathology. PubMed:22299660

path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") View Subject | View Object

Similar endosomal anomalies develop gradually in Down syndrome brain, beginning decades before the appearance of classical AD pathology (Cataldo et al. 2000). PubMed:22908190

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.