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path(MESH:"Autistic Disorder")

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Entity

Name
Autistic Disorder
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73ec5665b99a7a4b84edd84bbd46b34fac335358/external/mesh-names.belns

Appears in Networks 3

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0

Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP v1.0.0

In-Edges 8

p(FPLX:CHRN) association path(MESH:"Autistic Disorder") View Subject | View Object

Decline, disruption, or alterations of nicotinic cholinergic mechanisms have been implicated in various dysfunctions, such as schizophrenia, epilepsy, autism, Alzheimer’s disease (AD), and addiction (17–23). PubMed:17009926

Appears in Networks:

act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

Appears in Networks:

p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

Appears in Networks:

a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder") View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

Appears in Networks:

a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder") View Subject | View Object

Interestingly, we detected sex-specific differences in object/ mouse preference in the female mice, which did not prefer mice over objects (potential autistic behavior). The indifference phenotype was ameliorated by NAP treatment (Figure 7D). PubMed:30106381

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP) association path(MESH:"Autistic Disorder") View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

Appears in Networks:

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder") View Subject | View Object

Interestingly, we detected sex-specific differences in object/ mouse preference in the female mice, which did not prefer mice over objects (potential autistic behavior). The indifference phenotype was ameliorated by NAP treatment (Figure 7D). PubMed:30106381

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP) decreases path(MESH:"Autistic Disorder") View Subject | View Object

Ninety-three percent of the individuals present with autistic features (Fig. 3-B). Sixty-seven percent of them have been reported to have a clinical diagnosis of ASD. PubMed:29724491

Appears in Networks:

Out-Edges 5

path(MESH:"Autistic Disorder") association p(FPLX:CHRN) View Subject | View Object

Decline, disruption, or alterations of nicotinic cholinergic mechanisms have been implicated in various dysfunctions, such as schizophrenia, epilepsy, autism, Alzheimer’s disease (AD), and addiction (17–23). PubMed:17009926

Appears in Networks:

path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

Appears in Networks:

path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) View Subject | View Object

Nicotinic mechanisms contribute to cognitive function, and the decline of nicotinic mechanisms or loss of nAChRs has been observed in AD, dementia with Lewy bodies, Down syndrome, autism, and Parkinson’s disease (20, 140). PubMed:17009926

Appears in Networks:

path(MESH:"Autistic Disorder") association p(HGNC:ADNP) View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

Appears in Networks:

path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404) View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.