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bp(GO:"protein oxidation")

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Entity

Name
protein oxidation
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

Molecular chaperones and proteostasis regulation during redox imbalance v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 8

a(CHEBI:radical) increases bp(GO:"protein oxidation") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

bp(GO:aging) association bp(GO:"protein oxidation") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") View Subject | View Object

PDI is a redox sensitive chaperone that acts not only as a sensor but also as a protein involved in the processing of oxidized proteins and in preventing misfolding and/or aggregation of proteins. PubMed:24563850

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

path(MESH:Neoplasms) association bp(GO:"protein oxidation") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

a(CHEBI:heme) positiveCorrelation bp(GO:"protein oxidation") View Subject | View Object

Besides its physiological importance, heme has a potent oxidative capacity oxidizing lipids (Tappel, 1953, 1955; Vincent et al., 1988) and proteins (Aft and Mueller, 1984; Vincent, 1989), and damaging DNA (Aft and Mueller, 1983). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Oxidative Stress") positiveCorrelation bp(GO:"protein oxidation") View Subject | View Object

Oxidation of proteins result in stable carbonyl groups on amino acid side chains, and protein carbonyl content is one of the most widely used marker of protein oxidation and a general indicator of oxidative stress (Dalle-Donne et al., 2003). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

Out-Edges 7

bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) View Subject | View Object

Previous studies have demonstrated that oxidized proteins accumulate inside multivesicular bodies (Cannizzo et al., 2012), suggesting that oxidation may be a prerequisite to complete internalization of tau by e-MI, and that the LE environment may contribute to that modification PubMed:29024336

Appears in Networks:
Annotations
MeSH
Multivesicular Bodies
Confidence
High
MeSH
Brain

bp(GO:"protein oxidation") association bp(GO:aging) View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

bp(GO:"protein oxidation") association path(MESH:Neoplasms) View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

bp(GO:"protein oxidation") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Besides its physiological importance, heme has a potent oxidative capacity oxidizing lipids (Tappel, 1953, 1955; Vincent et al., 1988) and proteins (Aft and Mueller, 1984; Vincent, 1989), and damaging DNA (Aft and Mueller, 1983). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

bp(GO:"protein oxidation") positiveCorrelation bp(MESH:"Oxidative Stress") View Subject | View Object

Oxidation of proteins result in stable carbonyl groups on amino acid side chains, and protein carbonyl content is one of the most widely used marker of protein oxidation and a general indicator of oxidative stress (Dalle-Donne et al., 2003). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.