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p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Tau isoform F (441 aa)
Namespace
HBP
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cf4d8bb88754f036b943b4d94ad96e103dcb7149/export/hbp-names.belns

Appears in Networks 1

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 2

a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) View Subject | View Object

However, recent work by Cripps et al. (2006) successfully used MC1 (a monoclonal specific for an abnormal PHF-like conformation of tau) to affinity purify soluble full-length tau from PHF-rich extracts of AD cortex and subject it to liquid chromatography–tandem MS (LC–MS/MS) analysis. The presence of K6, K11, and K48- linked polyubiquitinations—in addition to monoubiquitination—was observed. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) association a(HBP:"paired helical filaments") View Subject | View Object

However, recent work by Cripps et al. (2006) successfully used MC1 (a monoclonal specific for an abnormal PHF-like conformation of tau) to affinity purify soluble full-length tau from PHF-rich extracts of AD cortex and subject it to liquid chromatography–tandem MS (LC–MS/MS) analysis. The presence of K6, K11, and K48- linked polyubiquitinations—in addition to monoubiquitination—was observed. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.