1. Catalog
  2. Nodes
  3. complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C))

complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

PP2A and Alzheimer Disease v1.0.0

In-Edges 2

p(FPLX:PPP2C, pmod(Me)) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) View Subject | View Object

Car- boxyl methylation of the catalytic subunit is required for efficient in vivo assembly of the trimer C, A, and B [63-65]; a process that is balanced by the opposite actions of methyl- transferase type IV (PPMT) and the methylesterase PME-1 [66-70]. PubMed:22299660

Appears in Networks:

p(FPLX:PPP2C, pmod(Me, Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) View Subject | View Object

PP2A C methylation at Leu309 is reduced in AD and this seems to contribute to PP2A C dysfunction by impairing the assembly of the trimer [77, 78]. PubMed:22299660

Appears in Networks:

Out-Edges 3

complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) hasComponent p(FPLX:"PPP2R_A") View Subject | View Object

Appears in Networks:

complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) hasComponent p(FPLX:"PPP2R_B") View Subject | View Object

Appears in Networks:

complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) hasComponent p(FPLX:PPP2C) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.