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path(MESH:"Knee Injuries")

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Entity

Name
Knee Injuries
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

bp(GO:"inflammatory response") positiveCorrelation path(MESH:"Knee Injuries") View Subject | View Object

Lately, much evidence has emerged to support a central role for participation of local inflammatory pathways in the disease processes (Scanzello, 2017), particularly so after knee injury (Goldring and Otero, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

path(MESH:"Osteoarthritis, Knee") positiveCorrelation path(MESH:"Knee Injuries") View Subject | View Object

Obesity, genetic factors, and aging are some of the most prominent risk factors (Sharma et al., 2006), and in the younger population, previous knee injury is an important contributor to increased prevalence of knee OA – as much as half of those sustaining a knee injury in their 20s had developed posttraumatic knee OA in the following 12 to 14 years (Lohmander et al., 2004, 2007; von Porat et al., 2004). PubMed:30505280

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 5

path(MESH:"Knee Injuries") positiveCorrelation path(MESH:"Osteoarthritis, Knee") View Subject | View Object

Obesity, genetic factors, and aging are some of the most prominent risk factors (Sharma et al., 2006), and in the younger population, previous knee injury is an important contributor to increased prevalence of knee OA – as much as half of those sustaining a knee injury in their 20s had developed posttraumatic knee OA in the following 12 to 14 years (Lohmander et al., 2004, 2007; von Porat et al., 2004). PubMed:30505280

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Knee Injuries") positiveCorrelation bp(GO:"inflammatory response") View Subject | View Object

Lately, much evidence has emerged to support a central role for participation of local inflammatory pathways in the disease processes (Scanzello, 2017), particularly so after knee injury (Goldring and Otero, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

path(MESH:"Knee Injuries") increases p(HGNC:HBB) View Subject | View Object

Altogether, our best interpretation of these data is that increased levels of cell-free Hb and heme in synovial fluid early after injury triggered an increase in the synovial fluid A1M concentration that appeared to be protective of oxidative damage. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Knee Injuries") increases a(CHEBI:heme) View Subject | View Object

Altogether, our best interpretation of these data is that increased levels of cell-free Hb and heme in synovial fluid early after injury triggered an increase in the synovial fluid A1M concentration that appeared to be protective of oxidative damage. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Knee Injuries") increases p(HGNC:AMBP) View Subject | View Object

Altogether, our best interpretation of these data is that increased levels of cell-free Hb and heme in synovial fluid early after injury triggered an increase in the synovial fluid A1M concentration that appeared to be protective of oxidative damage. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.