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  3. path(MESH:"Plaque, Atherosclerotic")

path(MESH:"Plaque, Atherosclerotic")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Plaque, Atherosclerotic
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 8

a(CHEBI:"carbonyl group") positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Gruel from advanced plaque also contains large amounts of organic soluble carbonyls and aldehydes that are also cytotoxic. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Earlier chemical investigations of gruel from advanced lesions revealed that it contains ceroid-like insoluble material composed mainly of hydoxyapatite, iron and calcium. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

a(CHEBI:"low-density lipoprotein") positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Low-density lipoprotein is the major lipid involved in plaque formation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:Aldehydes) positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Gruel from advanced plaque also contains large amounts of organic soluble carbonyls and aldehydes that are also cytotoxic. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

a(MESH:Calcium) positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Earlier chemical investigations of gruel from advanced lesions revealed that it contains ceroid-like insoluble material composed mainly of hydoxyapatite, iron and calcium. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

a(MESH:Hydroxyapatites) positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Earlier chemical investigations of gruel from advanced lesions revealed that it contains ceroid-like insoluble material composed mainly of hydoxyapatite, iron and calcium. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

p(HGNC:HBB, pmod(Ox)) positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Thus, it appears that these extracts oxidize ferrohemoglobin to ferrihemoglobin, thereby leading to heme instability and heme-mediated initiation of lipid peroxidation. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

p(HGNC:HMOX1) negativeCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Expression of HO-1 provides protection against atherosclerosis in several experimental models17,18 and HO-1 deficiency in humans has been associated with the appearance of vasculature fatty streaks and atheromatous plaques at age of six.19 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis

Out-Edges 8

path(MESH:"Plaque, Atherosclerotic") negativeCorrelation p(HGNC:HMOX1) View Subject | View Object

Expression of HO-1 provides protection against atherosclerosis in several experimental models17,18 and HO-1 deficiency in humans has been associated with the appearance of vasculature fatty streaks and atheromatous plaques at age of six.19 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Thus, it appears that these extracts oxidize ferrohemoglobin to ferrihemoglobin, thereby leading to heme instability and heme-mediated initiation of lipid peroxidation. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation a(MESH:Hydroxyapatites) View Subject | View Object

Earlier chemical investigations of gruel from advanced lesions revealed that it contains ceroid-like insoluble material composed mainly of hydoxyapatite, iron and calcium. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Earlier chemical investigations of gruel from advanced lesions revealed that it contains ceroid-like insoluble material composed mainly of hydoxyapatite, iron and calcium. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation a(MESH:Calcium) View Subject | View Object

Earlier chemical investigations of gruel from advanced lesions revealed that it contains ceroid-like insoluble material composed mainly of hydoxyapatite, iron and calcium. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation a(CHEBI:"carbonyl group") View Subject | View Object

Gruel from advanced plaque also contains large amounts of organic soluble carbonyls and aldehydes that are also cytotoxic. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation a(MESH:Aldehydes) View Subject | View Object

Gruel from advanced plaque also contains large amounts of organic soluble carbonyls and aldehydes that are also cytotoxic. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation a(CHEBI:"low-density lipoprotein") View Subject | View Object

Low-density lipoprotein is the major lipid involved in plaque formation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.