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bp(GO:mitophagy)

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Entity

Name
mitophagy
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 9

g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) View Subject | View Object

Fourth, genetic mutations and anomalies of presenilin 1, a dominant negative gene linked to AD, are associated with reduced lysosomal v-ATPase-mediated acidifica- tion 40,63 , a compromised ALN and deficient mitophagy 64 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(FPLX:AMPK) decreases bp(GO:mitophagy) View Subject | View Object

The heterotrimeric serine/threonine kinase 5ʹ‑AMP‑ activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1) trigger autophagy and repress mitophagy 3,10,20–23 (BOX 2; FIG. 3) . PubMed:30116051

Appears in Networks:

p(FPLX:mTORC1) decreases bp(GO:mitophagy) View Subject | View Object

The heterotrimeric serine/threonine kinase 5ʹ‑AMP‑ activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1) trigger autophagy and repress mitophagy 3,10,20–23 (BOX 2; FIG. 3) . PubMed:30116051

Appears in Networks:

p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) View Subject | View Object

First, autosomal recessive forms of early-onset PD are associated with mutations in PTEN-induced putative kinase protein 1 (PINK1) and the E3 ubiquitin-protein ligase parkin; these mutations lead to deficits in the mitophagic removal of damaged mitochondria 69,70 (BOX 2) . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) View Subject | View Object

First, autosomal recessive forms of early-onset PD are associated with mutations in PTEN-induced putative kinase protein 1 (PINK1) and the E3 ubiquitin-protein ligase parkin; these mutations lead to deficits in the mitophagic removal of damaged mitochondria 69,70 (BOX 2) . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) View Subject | View Object

In a similar vein, PSEN1 A246E mutant cortical neurons have reduced mitophagy compared to control neurons, which is associated more with decreased lysosomal function rather than mitochondrial targeting [132]. PubMed:29758300

Appears in Networks:

path(HBP:"mitochondrial dysfunction") increases bp(GO:mitophagy) View Subject | View Object

Thus, as a quality control mechanism, mitophagy − a form of selective macroautophagy that specifically targets mitochondria − occurs in response to damaged or dysfunctional mitochondria in order to prevent mitochondrial bioenergetic deficits. PubMed:29758300

Appears in Networks:

path(MESH:"Alzheimer Disease") increases bp(GO:mitophagy) View Subject | View Object

A recent study reported that mitophagy is robustly induced in AD brains and in vitro models of mutant APP, accompanied with abnormal accumulation of depoloarized mitochondria [126] PubMed:29758300

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:PRKN) increases bp(GO:mitophagy) View Subject | View Object

The E3 ligase Parkin, a protein implicated in Parkinson’s disease, creates an autophagy signal on mitochondria and also tags proteins elsewhere for proteasomal degradation (Yoshii et al. 2011). PubMed:22908190

Appears in Networks:

Out-Edges 2

bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) View Subject | View Object

Fourth, genetic mutations and anomalies of presenilin 1, a dominant negative gene linked to AD, are associated with reduced lysosomal v-ATPase-mediated acidifica- tion 40,63 , a compromised ALN and deficient mitophagy 64 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:mitophagy) isA bp(GO:macroautophagy) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.