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Entity

Name
autophagosome-lysosome fusion
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 1

In-Edges 6

a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") View Subject | View Object

Once formed, new autophagosomes move through a stepwise maturation process that culminates with fusion to a lysosome permitting degradation of the lumenal contents. PubMed:18930136

a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") View Subject | View Object

Microtubule-based vesicular trafficking is essential for delivery of autophagosomes to lysosomes and subsequent fusion [46], and impaired dynein-mediated trafficking is associated with impaired autophagosome/ lysosome fusion and reduced protein turnover [47,48]. PubMed:18930136

a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") View Subject | View Object

Microtubule-based vesicular trafficking is essential for delivery of autophagosomes to lysosomes and subsequent fusion [46], and impaired dynein-mediated trafficking is associated with impaired autophagosome/ lysosome fusion and reduced protein turnover [47,48]. PubMed:18930136

bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") View Subject | View Object

These processes are distinguished from macroautophagy, in which an isolation membrane expands to engulf a portion of the cell, eventually fusing to form a new autophagic vacuole that subsequently fuses with a lysosome [12]. PubMed:18930136

p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") View Subject | View Object

Rab7 participates in trafficking autophagosomes and fusion with lysosomes and disease-causing mutations are predicted to impair this process [43–45]. PubMed:18930136

p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") View Subject | View Object

Rab7 participates in trafficking autophagosomes and fusion with lysosomes and disease-causing mutations are predicted to impair this process [43–45]. PubMed:18930136

Out-Edges 2

bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") View Subject | View Object

Once formed, new autophagosomes move through a stepwise maturation process that culminates with fusion to a lysosome permitting degradation of the lumenal contents. PubMed:18930136

bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) View Subject | View Object

Several lines of evidence suggest that there is an impairment of autophagy resulting from impaired autophagosome-lysosome fusion combined with decreasing efficiency of the lysosomal system [60]. PubMed:18930136

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.