bp(GO:vasoconstriction)
The extensive crosslinkage of cell-free hemoglobin in a high-molecular weight HBOC retains cell-free hemoglobin dimers in the intravascular compartment, thereby preventing extravasation 112 of cell-free hemoglobin into the muscular layer of the arteries where local NO consumption can trigger vasoconstriction (25). PubMed:28314763
Heme promotes endothelial dysfunction by inducing the expression of adhesion molecules and reducing nitric oxide (NO) availability, which causes vasoconstriction [9-14]. PubMed:28400318
Cell-free hemoglobin and its prosthetic group heme can contribute to organ dysfunction and death [1–4, 9–12]; the pathological mechanisms include nitric oxide consumption, vasoconstriction, oxidative injury to lipid membranes, activation of the transcription factor NF-κB, endothelial injury as well as iron-driven oxidative inhibition of glucose metabolism[10–14]. PubMed:29956069
Several studies in animals have supported the idea that infusion of free Hb, stored RBC supernatant (preservation solution + plasma), and Hb-containing microvesicles causes vasoconstriction, vascular dysfunction, and vascular injury.12,16–18 PubMed:27308950
Plasma hemoglobin scavenges nitric oxide and causes vasoconstriction, platelet aggregation and inflammation9,22–24. PubMed:27515135
Previous studies showed that db/db mice have enhanced 312 susceptibility to hemoglobin-induced vasoconstriction (25). PubMed:28314763
Schaer and colleagues 107 showed that administration of exogenous haptoglobin prevents extravasation of cell free hemoglobin and vasoconstriction in rats (18). PubMed:28314763
Thus, haemolysis results in NO scavenging, systemic vasoconstriction and increased blood stasis, thereby affecting one of the principle components of Virchow’s Triad. PubMed:25307023
Thus, haemolysis results in NO scavenging, systemic vasoconstriction and increased blood stasis, thereby affecting one of the principle components of Virchow’s Triad. PubMed:25307023
Plasma hemoglobin scavenges nitric oxide and causes vasoconstriction, platelet aggregation and inflammation9,22–24. PubMed:27515135
Heme promotes endothelial dysfunction by inducing the expression of adhesion molecules and reducing nitric oxide (NO) availability, which causes vasoconstriction [9-14]. PubMed:28400318
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.