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p(HGNC:NLRC4)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
NLRC4
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 3

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRC4) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) hasComponent p(HGNC:NLRC4) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4) View Subject | View Object

In addition, NLRC4 and ASC levels are upregulated in the brains of AD patients (Liu and Chan, 2014), suggesting a possible role of the NLRC4 inflammasome in AD pathogenesis PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

Out-Edges 3

p(HGNC:NLRC4) hasVariant p(HGNC:NLRC4, pmod(Ph, Ser)) View Subject | View Object

Appears in Networks:

act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) View Subject | View Object

In the context of NLRC4 activation, caspase 11 was shown to interact with cofilin. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Regulation of actin cytoskeleton subgraph

p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In addition, NLRC4 and ASC levels are upregulated in the brains of AD patients (Liu and Chan, 2014), suggesting a possible role of the NLRC4 inflammasome in AD pathogenesis PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.