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p(HGNC:MAPT, pmod(NGlyco))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau in physiology and pathology v1.0.0

In-Edges 2

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(NGlyco)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(NGlyco)) View Subject | View Object

In human AD brains, but not in normal brains, tau is modified by N‑glycosylation, which is proposed to help to maintain and stabilize PHF structure PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 4

p(HGNC:MAPT, pmod(NGlyco)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In human AD brains, but not in normal brains, tau is modified by N‑glycosylation, which is proposed to help to maintain and stabilize PHF structure PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:MAPT, pmod(NGlyco)) regulates a(HBP:"paired helical filaments") View Subject | View Object

In human AD brains, but not in normal brains, tau is modified by N‑glycosylation, which is proposed to help to maintain and stabilize PHF structure PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

Furthermore, N‑glycosylation may facilitate tau hyperphosphorylation, as it suppresses the dephosphorylation and accelerates the phosphorylation of tau, probably because it changes the conformation of tau PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Furthermore, N‑glycosylation may facilitate tau hyperphosphorylation, as it suppresses the dephosphorylation and accelerates the phosphorylation of tau, probably because it changes the conformation of tau PubMed:26631930

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.