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Appears in Networks 2

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

In-Edges 3

p(HGNC:CHRM1) association a(MESH:Thalamus) View Subject | View Object

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory PubMed:24590577

complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) View Subject | View Object

The most intense accumulation of 5-I-A-85380 was detected in both thalami, pons and midbrain, and both nuclei lentiformes PubMed:24762290

complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) View Subject | View Object

We found high correlation coefficients for four brain regions (right superior parietal lobule, left thalamus, right pos- terior subcortical region, and left posterior subcor- tical region) and two CERAD subtests (Word List Intrusions and Boston Naming Test), some of them were statistically significant. PubMed:24762290

Out-Edges 3

a(MESH:Thalamus) association p(HGNC:CHRM1) View Subject | View Object

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory PubMed:24590577

a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

The most intense accumulation of 5-I-A-85380 was detected in both thalami, pons and midbrain, and both nuclei lentiformes PubMed:24762290

a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

We found high correlation coefficients for four brain regions (right superior parietal lobule, left thalamus, right pos- terior subcortical region, and left posterior subcor- tical region) and two CERAD subtests (Word List Intrusions and Boston Naming Test), some of them were statistically significant. PubMed:24762290

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.