path(MESH:"Thrombotic Microangiopathies")
Heme may be implicated and contribute to the development of (i) bp(MESH: PubMed:26875449
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.